Her2 Codon 655 Polymorphism in Her2 Negative Lung Cancer Patients – New Proposal for One Old Diagnosis

The significance of HER2 and Ile/Val single nucleotide polymorphism (SNP) of HER2 in lung cancer can be useful for predicting progression of this neoplasm. Materials and Methods. We investigate immunohistochemicaly the expression of HER2 and single nucleotide polymorphism (SNP) in HER2 codon 655 we used RFLP – PCR analysis in 20 cases. We evaluated the correlation between the collected data and clinical and pathological parameters of investigated patients. The results were compared with clinical and pathological parameters of investigated patients. Results. After analysis of the results we found that 100% of the cases were negative for HER2. HER2 RFLP PCR analysis showed genotype AG in five patients (25%) and the rest 15 cases (75%) had АА (Ile/Ile) genotype. The analysis of SNP and the presence of lymph node metastasis showed tendency. Among the 20 patients with metastasis 80% had genotype АА (Ile/Ile) and 20% genotype AG (Ile/Val) (χ2=2.857; p=0.091). Conclusion. Our results indicate that SNP in HER2 655 codon and investigation of HER2 expression could be helpful to outline the prognosis for lung adenocarcinomas.